Vance Spencer (@pythianism) — Twitter Score 726 out of 1000

Vance Spencer is the co-founder of Framework Ventures, a crypto venture firm he co-founded with Michael Anderson in 2019 that was among the first VC firms to concentrate on DeFi. He also co-founded Hashletes, an NFL-officially-licensed blockchain-based digital collectibles startup backed by Khosla Ventures, in 2018; the company was sold to JDS Sports in 2019. Vance Spencer's Twitter Score is 726 out of 1000 (an Excellent rating) as of July 2026, placing him at rank #111 (top 0.1%) out of 389,201 tracked accounts, with 168,256 followers as of July 2026.

Vance Spencer built Framework Ventures around early DeFi investments in Chainlink, Aave, Synthetix, and The Graph. The firm raised a $100 million second fund in 2021 and a $400 million third fund in 2022, with half of that fund earmarked for web3 gaming. A $400 million fourth fund was announced in June 2026, expanding the mandate into AI, robotics, and energy alongside crypto, with an LP base that includes funds of funds, an Ivy League endowment, sovereign wealth funds, and nonprofits. As of December 2025, Framework Ventures held approximately $1.28 billion in assets under management, deploying checks between $250,000 and $40 million per round. Its current portfolio includes positions in Hyperliquid, Sky (formerly Maker/DAI), and Plasma, a stablecoin-focused blockchain.

Vance Spencer has published 8,087 posts on the account. He has been mentioned by 289 accounts, with 544 total mentions across the platform. Tracked holdings include Universe, Catalog, Moonwalk Fitness, Mecka and Merit Systems.

Who follows Vance Spencer on X?

Vance Spencer draws a following concentrated in crypto venture and DeFi circles. The accounts that follow Vance Spencer include 2,426 founders, 692 angel investors, 1,362 influencers and 106 VCs, among them Laura Shin, Chris Dixon, Toly, ZachXBT, Cobie and Erik Voorhees.